Venous Thrombosis occur when the blood coagulates in the vein and forms a solid clot that blocks the venous circulation. This blockage causes the leg to swell suddenly along with severe pain and redness of the lower extremity. Pulmonary embolism is an adverse outcome. The Deep Vein Thrombosis (known as DVT) is most alarming and requires emergency medical treatment. Diagnosis is established via Duplex Ultrasound (Venous Echo-Doppler). Treatment is based on Anticoagulant drugs. Responsible factors should be identified and addressed. The dose and duration of therapy are essentials to avoid complications such as recurrence and long term post-thrombotic syndrome.